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Saikosaponin A
Saikosaponin A         CAS  20736-09-8         Molecular Weight：780.993        Formula：C42H68O13  

Purity:                  HPLC98%
Appearance：     White powder
Test Method：    HPLC; Mass;NMR
Usage:                 For laboratory research use only,not for human or diganostic use。
Package              20mg~1g per bottle。
Storage：           Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

Plant Origin

The root of  Bupleurum chinense DC．

Description
   1. Saikosaponin A(SSA) has antiepileptic activity, can inhibit NMDA receptor current and persistent sodium current, and inhibit epileptiform discharges induced by 4AP in a dose-dependent manner.
   2. Saikosaponin A has anti-inflammatory activity, can decrease PMA plus A23187-induced cysteine-aspartic acid protease (caspase)-1 activity, and the number of nasal rubs and serum TNF-α level in the ovalbumin-sensitized allergic rhinitis mouse model, and inhibit the IL-1β production.
   3. Saikosaponin A extends to alcohol self-administration the capacity to suppress and self-administration in rats ,the GABA B receptor system is likely part of the neural substrate underlying the reducing effect of SSA on alcohol self-administration.
   4. Saikosaponin A as antioxidants improve antioxidant status, supplementation with curcumin and/or saikosaponin A suppress inflammation and fibrogenesis in rats with CCl4-induced liver injury, however, the combination has no additive effects on anti-inflammation and antifibrosis.
   5. Saikosaponin A is a novel agent in the treatment of osteoclast-related diseases, such as osteoporosis.
   6. Saikosaponin A could effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord.

References

[1]. Liu Y et al.Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.Int J Biol Sci 2018; 14(13):1923-1934.

[2]. Hong Y et al. Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy. Drug Design, Development and Therapy. 2018 Sep;12:2945-2958.

[3]. Kwon MH et al. Pharmacokinetics and Brain Distribution of the Active Components of DA-9805, Saikosaponin A, Paeonol, and Imperatorin in Rats. Pharmaceutics. 2018 Aug 20;10(3):133.

Hongying Zhang

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