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Red wine extract is rich in polyphenols and flavonoids: Phytochemicals whose antioxidant properties may exceed those of the more well known sources like vitamin A, vitamin C, vitamin E, and beta-carotene. Some people call these polyphenols "nature's biological response modifiers" because of their ability to support the immune system. One polyphenol in red wine extract is resveratrol, a potent antioxidant that occurs naturally in plants and is considered part of their natural defense system. Resveratrol is specifically found in grapevines with the highest concentration being in the grape skin.
Oligomeric proanthocyanidins inhibit a number of enzymes that degrade connective tissue such as elastase, collagenase, and hyaluronidase. Antioxidants also promote healthy circulation.

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