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Propylene glycol is often used in electronic cigarettes to improve flavour and create a better throat hit. A bottle of flavored ‘e-liquid’ for ‘vaping’ shows propylene glycol as the main ingredient. Propylene glycol is commonly used to deice aircraft.

 Propylene glycol is also used in various edible items such as coffee-based drinks, liquid sweeteners, ice cream, whipped dairy products and soda.

Like ethylene glycol, propylene glycol is able to lower the freezing point of water, and so it is used as aircraft deicing fluid. Water-propylene glycol mixtures dyed pink to indicate the mixture is relatively nontoxic are sold under the name of RV or marine antifreeze.

Propylene glycol is frequently used as a substitute for ethylene glycol in low toxicity, environmentally friendly automotive antifreeze. It is also used to winterize the plumbing systems in vacant structures