| Model: | 98% |
|---|---|
| Brand: | kosoherb |
| Origin: | Made In China |
| Category: | Agriculture & Foods / Agricultural Products & Resources / Plant Extract |
| Label: | Homoharringtonine , leukemia , Homoharringtonine |
| Price: |
US $350
/ G
|
| Min. Order: | 1 G |
| Last Online:07 Mar, 2019 |
Product Name: Homoharringtonine
Othere Name: Omacetaxine mepesuccinate [USAN]; Ceflatonin; Myelostat; 4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate; Cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa; Cephalotaxine 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate;
NSC 141633; BRN 5687925; CGX-635; Omapro; UNII-6FG8041S5B; 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
CAS No.: 26833-87-4
Chemical Formula: C29H39NO9
Formula Weight: 545.62g/mol
Assay: 98%
Appearance: Off-white powder
Identification method: Mass, NMR
Applicaton: Omacetaxine/ Homoharringtoninefor the determination and identification, pharmacological experiments.
Pharmacological effect: Omacetaxine/ Homoharringtonine cycle non-specific antineoplastic agents. Depolymerize ribosome; inhibit protein synthesis; reduce mitotic index of he tumor; decrease nucleic acid content of tumor tissue; mainly used in clinical acute promyelocytic leukemia; acute monocytic leukemia, acute myeloid leukemia and malignant lyMelting Pointhoma; can also be used for chronic myeloid leukemia, polycythemia vera psychosis.
|
TEST ITEM |
SPECIFICATION |
RESULTS |
|
Appearance |
Kind of white or light yellow crystalline powder |
Kind of white crystalline Powder |
|
Solubility |
Soluble in ethanol, methanol, Chloroform, Slightly soluble in water and ethyl ether |
Conform |
|
Assay (HPLC) |
95% -103% |
99.45% |
|
Melting Point |
143°C -147°C |
144°C-146°C |
|
Loss on Drying |
≤2.0% |
0.65% |
|
Heavy Metals |
≤20 ppm |
10ppm |
|
Total Impurities |
≤2.0% |
0.53% |
|
Known single impurities |
≤0.5% |
0.28% |
|
Unknown single impurities |
≤0.1% |
0.08% |
|
Residual Solvent |
Meets the requirements of ICH |
Conform |
|
Acetone |
≤5000ppm |
300ppm |
|
Methanol |
≤3000ppm |
58ppm |
|
Chloroform |
≤5000ppm |
400ppm |
|
Dichloromethane |
≤3000ppm |
Absence |
|
Microbial Limits |
||
|
Total aerobic microbial count |
≤1000 cfu/g |
60 cfu/g |
|
Yeast & Mold |
Absence |
Absence |
|
Salmonella species |
Absence |
Absence |
|
Escherichia Coli |
Absence |
Absence |
|
CONCLUSION |
Conform to the specifications |
|
