Home > Products > Chemicals > Other Chemicals

Betadex Sulfobutyl Ether Sodium Salt CAS No.: 182410-00-0

Description:

Zhiyuan Betadex Sulfobutyl Ether Sodium Salt is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into beta cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Betadex Sulfobutyl Ether Sodium Salt China occurs as a white amorphous powder.

Betadex Sulfobutyl Ether Sodium salt is an excipient mainly used in nitrogen-containing drugs. It has special affinity and inclusion properties for nitrogen-containing drugs.

Characteristics & Applications:

Betadex Sulfobutyl Ether Sodium Salt is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.The amount of Betadex Sulfobutyl Ether Sodium Salt that may be used is dependent on the purpose for inclusion in the formulation, the route of administration, and the ability of the cyclodextrin to complex with the drug being delivered.

Pharm Grade Betadex Sulfobutyl Ether Sodium salt is the sulfonated modified sodium salt of beta cyclodextrin,which is an anionic, highly water-soluble cyclodextrin derivative, can be well incorporated with drug molecules to form non-covalent complexes, thereby improving the stability, water solubility and safety of the drug , reducing nephrotoxicity, ease drug hemolysis, control drug release rate, mask bad odor, etc.

Betadex Sulfobutyl Ether Sodium Salt is derived from beta cyclodextrin, which is nephrotoxic when administered parenterally. However, studies have shown that Betadex Sulfobutyl Ether Sodium Salt is well tolerated at high doses, when administered via intravenous bolus injections, orally, and by inhalation. Up to 9 g/day may be administered by IV infusion in a licensed voriconazole formulation. The safety following high doses of Betadex Sulfobutyl Ether Sodium Salt intravenous administration in humans is continually being investigated.

Zhiyuan Betadex Sulfobutyl Ether Sodium Salt has been subjected to an extensive battery of in vitro and in vivo genotoxicity and pharmacological evaluations. No genotoxic or mutagenic changes were observed with Betadex Sulfobutyl Ether Sodium Salt administration. Betadex Sulfobutyl Ether Sodium Salt is biocompatible and exhibits no pharmacological activity. It is rapidly eliminated unmetabolized when administered intravenously.

Learn more information please visit https://www.zycydex.com/