Ascorbyl Palmitate Powder CAS 137-66-6
Product Description
| Product Name: |
Ascorbyl Palmitate |
| Synonyms: |
PALMITOYL L-ASCORBIC ACID;6-O-Palmitoyl ascorbate;Palmitoyl ascorbate;Ascorbyl Palmitate (2 g);Ascorbyl Palmitate (2 g) (AS);ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(P);Ascorbyl palMitate / 6-PalMitoylascorbic acid;VitaMin C Oil Soluble /L-Ascorbyl PalMitate |
| CAS: |
137-66-6 |
| MF: |
C22H38O7 |
| MW: |
414.53 |
| EINECS: |
205-305-4 |
| Product Categories: |
Cosmetics raw materials; whitening and lightening raw materials |
| Melting point |
115-118 °C(lit.) |
| alpha |
+21～+26°(20℃/D, c=2, C2H5OH) |
| Boiling point |
512.7±50.0 °C(Predicted) |
| density |
1.150±0.06 g/cm3(Predicted) |
| refractive index |
22.5 ° (C=1, EtOH) |
| storage temp. |
2-8°C |
| solubility |
Slightly soluble in ethyl alcohol. |
| pka |
3.96±0.10(Predicted) |
| form |
neat |
| color |
White to Pale Gray |
| Description |
Ascorbyl palmitate is a lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; ) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics. |
| Chemical Properties |
Light yellow powder |
| Chemical Properties |
Ascorbyl palmitate is a practically odorless, white to yellowish powder. |
| Uses |
Ascorbyl Palmitate is an ester formed from ascorbic acid (A786990) and palmitic acid (P144500) creating a fat soluble form of vitamin C. Ascorbyl Palmitate is also used as an antioxidant food additiv e. |
| Uses |
ascorbyl palmitate is used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity. |
| Uses |
Ascorbyl Palmitate is an antioxidant formed by combining ascor- bic acid with palmitic acid. ascorbic acid is not fat soluble but ascor- byl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, col- ors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination. |
| Definition |
A white or yellowish-white powder having a citrus-like odor. Mp 116–117C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water. |
| Production Methods |
Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid. |
| General Description |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries. |
| Pharmaceutical Applications |
Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions. |
| Biochem/physiol Actions |
6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage. |
| Safety Profile |
When heated to decomposition it emits acrid smoke and irritating fumes. |
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