Model: | 122463 |
---|---|
Brand: | Seebio |
Origin: | Made In China |
Category: | Chemicals / Fine Chemicals |
Label: | 2-Hydroxypropyl-β-cy , beta cyclodextrin , excipient |
Price: |
US $1
/ pc
|
Min. Order: | 1 pc |
Last Online:18 Dec, 2019 |
Hydroxypropyl - β - cyclodextrin molecular structure and physico-chemical properties | |
Β - cyclodextrin by seven glucose units constitute each glucose residues of 2 - 3 -, 6 --hydroxy in hydroxypropyl hydrogen atom can be replaced. 2 - hydroxypropyl - β - cyclodextrin mainly 2 --hydroxy hydrogen atoms substituted product. Compared with β - cyclodextrin, its nature has undergone great change. ① appearance: β - cyclodextrin is white crystals, and 2 - hydroxypropyl - β - cyclodextrin as amorphous glass state body, after grinding for the white powder. ② solubility: β - cyclodextrin solubility smaller, at room temperature only 1.8 g / 100 g water, this also limits its application, and compared with β - cyclodextrin, 2 - hydroxypropyl - β - ring paste Solubility very fine, usually at room temperature> 50 g / 100 g of water, so it can not be in the alcohol solution crystallization. ③ Stability: β - cyclodextrin, 2 - HP-β - cyclodextrin molecules without reducing the thermal and light stability, tolerance 80 ℃ and 4500 lx illumination for 10 days, pressing its solution can be sterilized, in alkaline medium stability, strong acid instability, be strong acid decomposition ④ the metabolic pathway in the body: 2 - HP-β - CD is not gastric acid and alpha-amylase hydrolyzed, almost not participate in the body metabolism, not cumulative. After oral administration to complete all basically in the form of feces excreted, non-intestinal administration basically in the form of integrity with urine excretion. ⑤ toxicity and hemolytic: β - CD renal toxicity, hemolytic and irritating, it is not possible for non-intestinal administration, and 2 - HP-β - CD no renal toxicity, but also because of surfactant low, the role of hemolytic and irritating. ⑥ the complex and the drug release: As chemical structure changes, 2 - HP-β - cyclodextrin and β - CD on the same drug complexation capacity and the main object will be different molecular ratio of β - cyclodextrin in the body of complexation of sustained-release drugs, and the 2 - HP-β - CD release on the role of promoting drugs, biological drugs in the body can prompt release. |
Product: | 2-Hydroxypropyl-β-cyclodextrinHP-β-CD |
Grade | EP5 Grade |
Lot: | OH |
Code: | 122463 |
CAS-No: | [9 |
Mol. Formula: | (C42H70-nO35) (C3H7O) n |
Mol. Weight: | ~1046.0 |
Packing: |
Purity | >98.0% |
Solubility | > |
Identification A B | Complies with the tests |
Specific rotation | +128.0~+145.0° |
Acidity & AIKalinity pH | 5.0~8.0 |
Loss on drying | <5.0% |
Residue on ignited | <0.5% |
Related substances | Impurity A – NMT 1.5% Impurity B – NMT 2.5 % Other impurities – NMT 0.1% Total of other impurities – 1.0% max |
Chloride | <0.018% |
Heavy metal(Pb) | ≤20ppm |
Arsenic | <4ppm |
Conductivity | ≤200 uS·cm-1 |
Molar substitution | 0.4-1.5 |
Microbial contamination | |
Bacteria | ≤100 cfu/g |
Fungi | ≤100 cfu/g |
Escherichia coli | None detected |
Salmonella | None detected |
Bacterial endotoxins | ≤10 IU/g |
Appearance of solution | Clear and colourless |
Appearance | White powder |