Products for Solid Phase Peptide Synthesis/Combinatorial Chemistry
Tulsion®CMB Polymers提供固相合成肽生物科技
特麦仕制造特殊等级的杜笙 Polymers 用于生物科技固相法的肽合成步骤使用。
Thermax make  ecial Tulsion® Polymers having applications in the biotechnology area specially for solid phase peptide synthesis .
杜笙 CMB 高分子树脂具有能应用于肽的合成的甲基氯官能基.以此种树脂用来合成肽的技术是由Merrified 于1963年发明。肽的化学键的行成是由此种树脂的官能基与氨基酸键结合而来。在去除保护的官能基之后，一个个新的氨基酸分子便产生来增加其肽的化学键。 此肽的化学键的增长是一步一步合成而来的。在每个步骤中过滤掉多余的反应剂。在最后的合成步骤是去除所有的保护官能基并将肽从此树脂中分离出来。此种树脂 的特性可以根据客户需要制造，用来适用不同的合成步骤。它们根据严格的质量标准在非常认真的控制条件下制造。

Tulsion® CMB polymers have chloromethyl functionality and are used for peptide synthesis.Use of such polymers for peptide synthesis was initiated by Merrifield in 1963. The formation of peptide bond starts with reaction of a protected amino acid molecule with chloromethyl group on the surface of the polystyrene polymer. After removal of the protecting group, a new amino acid molecule is reacted to elongate the peptide chain. The elongation is continued with stepwise addition. Excess reagents and byproducts are removed by filtration at each step. The final step in the synthesis involves freeing up of the protecting group as well as liberating the peptidefrom the polymer. Properties of the polymers can be tailor-made to suit individual application needs.

They are made under very carefully controlled conditions using strictest quality standards.

Tulsion® CB polymers:

所有高分子合成的基础是聚合物基质。Tulsion® CB 100 / 200
是最常用的型号。固相有机合成的最重要考虑因素是树脂的颗粒大小及膨胀因素。而膨胀因素是由树脂本身的键结程度 ,水合以及物质的特性有关。
Tulsion®CB 100 / 200 本身特质具有很好的疏水特性并且在非极性的溶剂中膨胀。他们用于固相的有机合成与DVB 产生交叉键结而具有稳定的机械结构.

The foundation of all polymeric synthesis is the polymeric matrix. Tulsion®CB 100 / 200 is commonly used resin. The most important characteristics considering solid phase organic synthesis are the swelling factor and the bead size of the resin. The swelling characteristics areaffected by the factors such as degree of crosslinking, hydrophobisity of substrate and nature ofthe matrix.

Tulsion® CB 100 / 200 itself is very hydrophobic in nature and swells in a non-polar solvent. It is used in solid phase organic chemistry is crosslinked with DVB to give mechanically stable matrix in presence of swelling solvents.

Tulsion®CB 100 / 200 树脂能用于各种合成反应，在反应中作为甲基氯树脂或Merrifield 树脂(Tulsion®CMB) ,Wang Resins, 或者其他用于固相肽合成的树脂。

Tulsion®CB 100 / 200 resins are used in variety of reactions to give Chloromethyl resins or Merrifield resins (Tulsion®CMB), Wang resins chlorotrytil resins and other resins used in solidphase peptide synthesis.

技术资料

Technical Characteristics -

Tulsion®	CMB 100	CMB 200	CB 100	CB 200
结构 Matrix Structure	交联聚苯乙烯 Crosslinked Polystyrene	交联聚苯乙烯 Crosslinked Polystyrene	交联聚苯乙烯 Crosslinked Polystyrene	交叉键结高分子Crosslinked Polystyrene
官能基 Functional  Group	氯甲基 Chloromethyl	FB(Free Base) . 自由基	苯氛 Plane Polystyrene	苯氛 Plane Polystyrene
颗粒大小 Particle Size  (ASTM)	100 – 200	200 – 400	100 – 400	200 - 400
总氯含量 Total Chloride Content (meq/dry gm)	0.8 – 0.4	4 – 0.4	-	-
最大含水量 , %Moisture Content Max	1	1	1	1
溶解率 Solubility	不溶于所有的溶剂 Insoluble in all solvent	不溶于所有的溶剂 Insoluble in all solvent	不溶于所有的溶剂 Insoluble in all solvent	不溶于所有的溶剂 Insoluble in all solvent
特性 Features	颗粒状 Free flowing spherical beads	颗粒状 Free flowing spherical beads	颗粒状 Free flowing spherical beads	颗粒状 Free flowing spherical beads

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