Due to its good scale inhibition and high temperature tolerance properties, HPMA is widely used in desalination plant of flash vaporization equipment, low pressure boiler, steam locomotive, crude oil evaporation, petroleum pipeline, and industrial circulating cool water systems. In addition, HPMA has good corrosion inhibition effect when used together with zinc salt. HPMA can also used as additives for cement.

HPMA is usually used together with organic phosphonate at dosage of 1-15ppm for circulating cool water system, oilfield fill water, crude oil dewatering and low-pressure boilers. HPMA has good scale inhibition (98%) and scale stripping properties. When used together with zinc salts, it can effectively inhibit carbon steel corrosion.