As a "natural" aspirin, salicin was used to treat mild fever, cold, infection (influenza), acute and chronic rheumatism, headache and pain caused by inflammation. Aspirin (acetylsalicylic acid), as a synthetic substitute salicin, has the potential risk of gastrointestinal side effects. As a natural configuration, salicin harmlessly through the gastrointestinal system, conerted to salicylic acid in the blood and liver. Transformation process takes a few hours, so the result will not immediately be felt by human body, but the general effect can last several hours.