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Artemether is a methyl ether derivative of artemisinin, which is a peroxide lactone isolated from the Chinese anti-malarial plant, Artemisia annua. Artemether, from the definition of Wikipedia,is an anti-malarial for the treatment of multi-drug resistant strains of falciparum malaria. Its combination (co-formulation) with Lumefantrine has first been marketed by Novartis under the brand names Riamet and Coartem. Today, this combination therapy is available as generic from several manufacturers, and Hunan keyuan Bio-products co., Ltd is one of the largest real manufacturers within China, with plant growing base and factory in Shaoyang, Hunan province, and Shanghai Natural Bio-engineering as the sales office and R&D center in Shanghai. Artemether is synthesized from Artemisinin using methanol and a catalyst in hydrochloric acid medium. This results in the production of predominantly βα-artemether. The alpha-epimer is also present and causes a difficult purification of the product. The pure alpha product behaves differently and has a melting point of 100 ℃ whereas the βα-epimer has a melting point of 84-86℃. Both the alpha and the βα-epimers are active antimalarials. It is the purification and separation of alpha fromβαthat leads to low yields and hence this increases the cost price of Artemether significantly.