http://www.creative-animodel.com/PK-PD/Drug-Metabolism-and-Pharmacokinetic-Services.html

Translational Research (PK) will be involved in the design and execution of in vivo PK/ADME studies and the evaluation of clinical pharmacokinetic data to support the development of Creative Animodel product candidates.

Creative Animodel conducts typical PK study which involves administering a fixed amount of the the (the dose) to the subject (various animals) and at various times post dose, samples of an easily accessible tissue (usually blood/plasma) are drawn and collected for analysis of the the and its metabolite concentrations.

Duties and responsibilities will include：

• Evaluating compounds in various formulations, both solution as well as suspension dosing in various species.

• Studying correlative aspects between the in vitro and in vivo metabolism of analogs to increase throughput and help lower cost.

• Dose escalation studies in rats or dogs with the potential for follow up in the 7- and 28-day tox studies in rats/dogs that would help plan for Phase I and in some cases Phase II clinical trials.

• Cassette (n-in-1) PK for early discovery compound screening and decision prioritization

• The distribution in tissue/organ and body fluid and determination of blood and brain ratio for brain penetration

• Metabolic kinetics with active metabolites

• PK analysis using WinNonlin