Product Name: Ibrutinib (PCI-32765)

CAS No.: 936563-96-1

Information: Bruton's tyrosine kinase (BTK) inhibitor

Description: Ibrutinib is a potent and highly selective inhibitor of Btk with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.

Other Names: PCI-32765,Ibrutinib,CRA-032765

Chemical Name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide

Canonical SMILES: C=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N

MF: C25H24N6O2

MW: 440.5

Purity: 99% min,

Appearance: White powder

Type: Antineoplastic Agents

Grade Standard: Medicine Grade

Solubility: Soluble in DMSO > 10 mM 

Storage: Desiccate at -20°C 

General tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. 

Shipping Condition: Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request

Background: Ibrutinib (PCI-32765), also named as Ibrutinib, is a Bruton tyrosine kinase inhibitor which is used to study the biological effects of Bruton tyrosine kinase inhibition on mature B-cell function and the progression of B cell-associated diseases in vivo. The Bruton tyrosine kinase is specifically necessary for BCR signaling as demonstrated by human and mouse mutations that disrupt Bruton tyrosine kinase function and prevent B-cell maturation at steps which need a functional BCR pathway. PCI-32765 also inhibited autoantibody production. Occupancy of the Bruton tyrosine kinase active site by PCI-32765 was monitored in vitro and in vivo using a fluorescent affinity probe for Bruton tyrosine kinase.

Brand Name: Huavet

Place of Origin: Shaanxi, China (Mainland)

Usage: Antineoplastic Agents

Inventory status: in stock

Shelf life: 2 years

Sample: Available

COA (Certificate of Analysis): Available

MSDS (Material Safety Data Sheet): Available

HPLC Spectrum: Available

ISO: Approved

GC: Available

NMR (Nuclear Magnetic Resonance): Available

Packaging Details:1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial quantity. Specific packing required by customer

Delivery Detail: Prompt shipment

 

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