Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 which is abundantly expressed in colon cancer cells. Also inhibits c-Jun, a transcription factor that plays a critical role in inflammation and carcinogenesis.

Berberine is a chemical found in several plants. People take berberine for heart failure. Some people apply berberine directly to the skin to treat burns and to the eye to treat trachoma, a bacterial infection that frequently causes blindness.

Anti-Inflammation

Berberine is able to activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase to fight against inflammation.

Weight Reduction

Berberine also plays a role in enhancing brown fat activity. Brown fat is a heat-generating type of fat that burns energy instead of storing it, and this may have important implications when it comes to weight loss

Improve Diabetes

Berberine was able to control blood sugar and lipid metabolism as effectively as metformin, with researchers describing berberine as a "potent oral hypoglycemic agent.

Liver Disease

Early research s ests that taking berberine for 12 weeks reduces fat in the blood and markers of liver damage in people with liver disease and diabetes.