Holothoracic multifrequency vibratory sputum excretion machine (airway clearance system) uses the technology of “high frequency of chest wall oscillation” (HFCWO). It send pulse signal through host machine, making inflatable vest (or chest strap) produce high-speed and repeated oscillation in high-frequency, and forming directional independent drainage, which will make the secretions of respiratory tract and deep lobes relax, liquefy and fall off, so sputum would move from the bronchial to the main trachea and be eliminated by cough or artificial suction.