Product Properties

Top grade Cooling Agent ws-12 Koolada ws-12 applied in foods and medicine field

Product Name: Cooling agent ws-12
Chemical Name: (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide

CAS No.: 68489-09-8
MF: C18H27NO2
MW: 289.4125
Appearance: White crystal powder
Odor:  Mild cooling, slight menthol odor (almost odorless)
Detection Method: HPLC
Purity: ≥99%
Melting Point: 179℃-183ºC

Flash Point: >100℃
Refractive Index: 1.528
Solubility: Soluble in 100% ethanol, methanol, ethyl acetate, , dimethyl formamide or acetonitrile; insoluble in water or DMSO
FEMA No.: 4681
Shelf Life: 2 years

Detailed Description

Cooling agent ws-12
CAS No.: 68489-09-8
WS-12 is a cooling agent and potent TRPM8 agonist (EC50 = 193 nM). High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC50 value ~2'000 times lower than that of (-)-menthol (Prod. No. ALX-420-042).
Usage:
1. Soluble in Ethanol/PG firstly, then adding water solution.
2. Or dissolved in flavors firstly, then added into your products.
3. Mixed with dementholized peppermint oil can increase the fragrance signally.

Advantages

Cooling agent ws-12
CAS No.: 68489-09-8

1. There is a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations and can bring more stimulative, fresh and aromatic sensory to the entire mouth and throat.
2. Its melting point is from 179°C to 183°C. It will not affect cooling perception of product even under temperature at 200°C.
3. Its cooling intensity can maintain 15~30 minutes and cooler than tradional menthol products.
4. When used with other flavors, it enhances the effects of the flavors. It also can be used with other cooling agents.