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According to traditional Chinese medicine, Auricularia auricula has the characteristics of calming lung, moistening intestines, nourishing Yin, nourishing blood, promoting blood circulation and removing blood stasis

 

Black fungus

 

Black fungus

 

, eye-catching, stomach nourishing, etc. It can be used to treat metrorrhagia, hemorrhoids, dysentery, anemia and constipation. At the same time, it contains fermenting element and botany alkali, which can promote the secretion of digestive tract and urinary gland, and cooperate with secretion to catalyze stone, which has obvious resolving effect on gallstone and kidney stone. The modern medical research on Auricularia auricula began in the 1980s, and it was first found that it has a significant effect on inhibiting platelet aggregation, which has attracted the world's attention. Wu Wutong et al. Extracted and separated important active components from Auricularia auricula. In the following 20 years, a lot of pharmacological researches have been carried out on Auricularia auricula polysaccharide, which reveals its extensive physiological activity and extremely high medical and health functions.

 

Improve the immune function of the body

 

Immunity is a physiological process for human and animals to prevent biological pathogenic factors. Chen Qionghua and others found that Auricularia auricula polysaccharide can increase the spleen index, half hemolysis value and E-rosette formation rate of mice, promote macrophage phagocytosis and lymphocyte transformation, and then improve the immune function of the body. Zhang Linghua et al. Reported that the humoral immunity and cellular immunity of mice increased significantly after intraperitoneal injection of Auricularia auricula polysaccharide. According to Zhang Caiqing et al., Auricularia auricula polysaccharide has little effect on the agglutination of red blood cells in rats, but can significantly enhance the phagocytic function of macrophages in mice.

 

antitumor activity

 

The antitumor effect of Auricularia auricula polysaccharide is produced indirectly by acting on the body's defense system. Its important mechanism is to enhance the immune function of the body's cells. Amisaki et al. Studied the correlation between the chemical structure of polysaccharide extracted from Auricularia auricula fruit body and its antitumor activity, and thought that the water-soluble glucan component in Auricularia auricula had obvious antitumor effect. The intraperitoneal injection of Auricularia auricula polysaccharide can inhibit the growth of solid tumor S180 in mice. The intravenous injection can inhibit Lewis lung tumor, B16 melanoma and H22 liver cancer, and the optimal effective dose is 20 μ g / kg. Zong canhua and other experimental studies found that Auricularia auricula polysaccharide can increase the serum NO content of H22 mice and promote the apoptosis of tumor cells.

 

Antiaging effect

 

Auricularia auricula polysaccharide has a protective effect on body damage and can delay tissue aging. It is considered to be an ideal anti-aging health care product. Wu xianrui and others reported that Auricularia auricula polysaccharide can significantly enhance the flying ability of Drosophila melanogaster and swimming endurance of mice, reduce the content of lipofuscin in the myocardium of mice, and improve the activity of SOD in the brain and liver of mice. Zhou Huiping et al reported that Auricularia auricula polysaccharide can prolong the life span of Drosophila melanogaster, increase the non-specific resistance of old mice to harmful stimulation, reduce the content of lipid peroxide in animal plasma, and reduce the production of lipofuscin.

 

Anti radiation effect

 

Chen Zhiqiang, et al. Injected 2 mg of Auricularia polysaccharide into the abdominal cavity of mice for 7 consecutive days. The mice were irradiated with 60Co γ - ray. The total dose was 800 roentgen. The results showed that the survival time of mice was 24 days longer than that of the control group one point five six The results showed that the polysaccharide of Auricularia auricula had protective effect on radiation cell injury. Fan Lisheng et al. Found that middle and high doses of Auricularia auricula polysaccharide solution were used to gavage mice 3.5Gy60Co The micronucleus rate of bone marrow and sperm aberration rate of mice were significantly reduced, the survival rate was improved, and the survival time was prolonged after γ - ray irradiation, which indicated that Auricularia auricula polysaccharide had a better anti radiation effect.

 

Anticoagulant effect

 

Auricularia auricula polysaccharide can inhibit platelet aggregation, and its mechanism is mainly to inhibit thrombin activity. Domestic research shows that 30 μ mol / L polysaccharide solution is used in vitro test 0.1mL And rabbit blood 0.9mL When mixed, the clotting time can be prolonged by 2 times. Mice were divided into three groups: intravenous injection, intraperitoneal injection and intragastric injection of 50mg / kg. The clotting time was longer than that of the control group Two point one , One point three and One point three Times.

 

Hypolipidemic effect

 

It has been reported that the polysaccharide of Auricularia auricula (300mg / kg / day) can significantly reduce the content of serum total cholesterol and atherosclerosis index, and improve the antioxidant capacity of serum and liver. Cai Xiaoling and others injected Auricularia auricula polysaccharide into hyperlipidemia mice every day. After one week, the content of cholesterol in the serum of mice decreased significantly. Zhou Guohua et al. Used different concentrations of Auricularia auricula polysaccharide to test the high-fat model mice. The results showed that the serum triglyceride, total cholesterol and low-density lipoprotein of the mice in Auricularia auricula polysaccharide group were lower than those in the control group, while the high-density lipoprotein was significantly higher than that in the control group, indicating that Auricularia auricula polysaccharide has the effect of lowering blood lipid.

 

Hypoglycemic effect

 

Zong canhua et al. Conducted an experimental analysis on the hypoglycemic effect of Auricularia auricula polysaccharide on diabetic mice,

 

Black fungus

 

Black fungus

 

The results showed that, compared with the model control group, the blood glucose of each dose group of Auricularia auricula polysaccharide decreased significantly 15 days after administration. Han chunran et al. Extracted polysaccharide from Auricularia auricula with cellulase and protease and studied its hypoglycemic function. The results showed that when the dosage was more than 200mg / kg, Auricularia auricula polysaccharide could significantly reduce the blood glucose value of diabetic mice, but had no effect on the blood glucose value of normal mice, indicating that Auricularia auricula polysaccharide had good prevention and control effect on diabetes.

 

Other functions

 

Shenjianhe et al. Found that Auricularia auricula polysaccharide can significantly prolong the formation time of specific thrombus and fibrin thrombus, shorten the length of thrombus, and reduce the wet and dry weight of thrombus. In addition, Auricularia auricula polysaccharide has many functions, such as anti ulcer, anti hepatitis, anti infection, anti mutation, promoting nucleic acid and protein biosynthesis.