L-type Ca2+ channels. Calcicludine is a potent and specific antagonist of neuronal L-type CaV channels1.

SPECIFICATION OF CALCICLUDINE

Product Name: Calcicludine (Calcicludine, L-type Ca2+ channel blocker)

CAT.#: C1020-V

CAS N0.: 178037-96-2

Sequence: WQPPWYCKEPVRIGSCKKQFSSFYFKWTAKKCLPFLFSGCGGNANRFQTIGECRKKCLGK(Disulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53)

Purity: > 98%

Solubility: Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Form/State: Lyophilized powder

Molecular weight: 6979

Molecular formula: C321H476N86O78S6

Source: Synthetic peptide

Shipping and storage: Shipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Storage of solutions: Up to two weeks at 4°C or three months at -20°C.

APPLICATION OF CALCICLUDINE

Calcicludine (CAC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons.

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