Product Name: GW0742
CAS:317318-84-6 
FW:C21H17F4NO3S2 
MW:471.4846 
EINCES：1532714-185-1
MP：134.5-135.5 °C
BP：591.5±60.0 °C(Predicted)
Density：1.46±0.1 g/cm3(Predicted)
Appearance:  White powder
Package: 10g,100g,500g and 1kg or as customers'request.
Test Method: HPLC
Purity:99% HPLC
Min Order: Powder---10gram
Payment:Bitcoin,Moneygram and Wester Union
Lead time:24hours after received payment
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What is GW0742？
GW0742 is a small molecule agonist of human peroxisome proliferator-activated receptor delta (PPARdelta). It shows an EC50 of 1.1 nM against PPARδ, 100-fold selectivity over other human subtypes.

Benefit:The effects of a high-affinity PPAR-β/δ agonist, GW0742, in a mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the pleural cavity of mice elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-α, and IL-1β. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation measured. Thus, based on these findings, we propose that a PPAR-β/δ agonist such as GW0742 may be useful in the treatment of various inflammatory diseases.

Application:GW0742 is a potent and selective agonist for PPARδ, a member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. It has been shown to reduce atherosclerosis in LDLR-/- mice, to exert protective actions in an autoimmune model of demyelinating disease, and to induce differentiation and inhibit proliferation in keratinocytes.

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