Afoxolaner for dogs is used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Gihi Chemicals also has afoxolaner for cats. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. When afoxolaner is prescribed for the treatment of mange, it is referred to as "extra label" or "off label" use.

 

Afoxolaner Synonym

4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide; Afoxolaner; 1-NaChemicalbookphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-; Afoxolanerfandachem

 

Afoxolaner Safety

CAS No.: 1093861-60-9

 

EC No.: 832-051-7

 

MF: C26H17ClF9N3O3

 

MW: 62.587

 

Parameters of Afoxolaner

Item	Specification	Results
Appearance	White To Off-white Crystalline Powder	Complies
Identification	HPLC: HPLC Retention Time Confirms To Standard	Complies
Melting Point	148-155℃	148-150℃
Water	≤0.1%	0.07%
Residue Solvents	Dichloromethane≤600ppm	N.D.
	Isopropyl Acetate≤5000ppm	N.D.
	Isopropanol≤890ppm	2ppm
	N, N-Dimethylformamide≤880ppm	N.D.
	Methanol≤3000ppm	N.D.
	Tetrahydrofuran≤720ppm	N.D.
	Triethylamine≤5000ppm	N.D.
Residue On Ignition	≤0.1%	0.02%
Related Substances	Impurity D≤0.15%	N.D.
	Impurity F≤0.15%	0.08%
	Individual Unknown Impurity≤0.10%	0.06%
	Total Impurities≤1.00%	0.38%
Assay(Anhydrous Substance)	98.0%~102.0%	99.10%

 

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Packing:

100g/bag; 500g/bag; 1kg/bag

 

Recommended storage method:

Store in a cool, dry and ventilated place.

 

Recommended storage temperature:

2 - 8 °C

 

Product usage:

Pharmaceutical intermediates

Benefits of Afoxolaner

Treat and control flea and tick infestations in dogs.

When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.

The treatment of sarcoptic mange or demodectic mange.

When afoxolaner is prescribed for the treatment of mange, it is referred to as 'extra label' or 'off label' use.

 

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