Good quality and low price High Purity 99% Research Chemical Phenacetin

Model:	62-44-2
Brand:	MF
Origin:	Made In China
Category:	Chemicals / Pharmaceutical Chemicals
Label:	-
Price:	US $10 / gram
Min. Order:	5 gram

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Product Description

Description

Phenacetin

Phenacetin structure	Common Name	Phenacetin
	CAS Number	62-44-2	Molecular Weight	179.216
	Density	1.0±0.1 g/cm3	Boiling Point	323.6±44.0 °C at 760 mmHg
	Molecular Formula	C10H13NO2	Melting Point	133-136 °C(lit.)
	MSDS	Chinese USA	Flash Point	149.5±28.4 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Phenacetin

Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].

Phenacetin Biological Activity

Description

Related Catalog

Research Areas >> Inflammation/Immunology

Target

COX-3:102 μM (IC50)

Solvent

In Vitro:

10 mM in DMSO

Solubility

1 mM	5.5797 mL	27.8987 mL	55.7973 mL
5 mM	1.1159 mL	5.5797 mL	11.1595 mL
10 mM	0.5580 mL	2.7899 mL	5.5797 mL

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

CC(NC1=CC=C(OCC)C=C1)=O

References

[1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31.

[2]. Brix, A.E., Renal papillary necrosis. Toxicol Pathol, 2002. 30(6): p. 672-4.

[3]. Dubach, U.C., B. Rosner, and T. Sturmer, An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med, 1991. 324(3): p. 155-60.

Related Molecules

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	323.6±44.0 °C at 760 mmHg
Melting Point	133-136 °C(lit.)
Molecular Formula	C10H13NO2
Molecular Weight	179.216
Flash Point	149.5±28.4 °C
Exact Mass	179.094635
PSA	38.33000
LogP	2.01
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.506
Stability	Stable. Incompatible with strong oxidizing agents, strong acids.
Water Solubility	0.076 g/100 mL

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.