Introduction
Polygonum multiflorum extract is the dried root tuber of Polygonum Polygonaceae, the main functional components are lecithin, emodin, rhein and other components.

Drug name: Polygonum multiflorum Thunb

Efficacy: nourishing essence and blood, black hair, strengthening bones and muscles, nourishing liver and kidney.

Active ingredients: tuberous roots contain anthraquinone compounds, mainly emodin, chrysophanol, physcion, rhein, and chrysophanol anthrone.

Plant source: Polygonum multiflorum, a perennial winding vine of Polygonaceae. The root is slender, the end becomes a fat tuberous root, the appearance is reddish-brown to dark brown. The gas is slightly bitter and the taste is slightly bitter and astringent.

Extracted parts: tubers

name
English name Radix polygoni mulitiflori P.E.
Latin name Polygonum multiflorum Thunb

effect
Anti-aging effect
Aging animals accumulate a large amount of lipid peroxidation products, accompanied by a decrease in superoxide dismutase activity. The experimental results show that Polygonum multiflorum can significantly reduce the content of malondialdehyde in the brain and liver tissue of aged mice, increase the content of monoamine transmitters in the brain, enhance the activity of SOD, and can also significantly inhibit the expression of monoamine oxidase-B in the brain and liver tissue of aged mice. Activation, thereby eliminating the damage of free radicals to the body, delaying the occurrence of aging and disease. The free radical theory believes that the generation and deposition of lipid peroxides can cause a series of aging symptoms, so the content of lipid peroxides is one of the main indicators for evaluating aging. The formation of the compound has a very obvious inhibitory effect, indicating that Polygonum multiflorum has the effect of delaying skin aging, and can be used as a good skin anti-aging cosmetic additive. In addition, Polygonum multiflorum can significantly improve the DNA damage repair ability of peripheral lymphocytes in aged rats, and by inhibiting the activity of monoamine oxidase-B in the brain, it affects the content of the central neurotransmitter in the organism, thereby regulating the activity of the central nervous system and delaying the aging of the brain.

Effects on the immune system
Polygonum multiflorum can antagonize the atrophy and degeneration of the thymus in mice caused by the immunosuppressants hydrocortisone or prednisolone, increase the weight of the thymus, adrenal gland, spleen and abdominal lymph nodes, increase the total number of white blood cells, and promote the phagocytosis of peritoneal macrophages function, reducing the content of circulating immune complexes in mice. Immunology believes that the decline of immune function is closely related to the aging of the body. The thymus is the central organ of the immune system and can effectively maintain the immune function of the body. Polygonum multiflorum can delay the degeneration of the thymus with aging, which may be an important mechanism for delaying aging and improving immunity. In addition, Polygonum multiflorum can also increase the content of nucleic acid and protein in the thymus, delay the age-related degeneration of the thymus in aged rats, and promote the reversal of the ultrastructure of the thymus in aged mice. The body's non-specific immune function.

Lowering blood lipids and anti-atherosclerosis
Experimental studies have shown that the intragastric administration of 0.84-8.4 g/kg·d of Polygonum multiflorum ethanol extract can significantly reduce the levels of plasma triglycerides and free cholesterol in aged quails within 6 weeks, and inhibit the increase of plasma total cholesterol and cholesterol esters. . The water extract of Polygonum multiflorum can significantly increase the serum high-density lipoprotein cholesterol content in mice, reduce the level of TC, and significantly increase the ratio of HDL-C/TC, s esting that Polygonum multiflorum can improve the body's ability to operate and remove cholesterol, and reduce blood lipid levels. Delay the development of atherosclerosis. The mechanism of the lipid-lowering effect of Polygonum multiflorum has not yet been clarified, and it may be completed by one of the following ways or synergistically: (1) The cathartic effect of anthraquinones accelerates the metabolism of toxins in the body and restores the fat metabolism pathway of the liver; (2) It effectively affects the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and Ta-hydroxylase in the liver, inhibits the synthesis of endogenous cholesterol, promotes the conversion of cholesterol into bile acids, and inhibits the release of bile acids from the intestines. Reabsorption and enhance the excretion of bile acids from the intestine; (3) induce liver microsomal carboxylesterase, promote the hydrolysis process in the body, and accelerate the excretion of toxins in the body. There are many links in the occurrence of atherosclerotic lesions, and the proliferation of smooth muscle cells is an important link. Experiments show that the compound traditional Chinese medicine containing Polygonum multiflorum can obviously inhibit the proliferation of bovine aortic smooth muscle, and the effect of its single herb is not as obvious as that of the prescription. Chen Wansheng et al. found that a new tetrahydroxy stilbene glycoside in Zhishouwu can inhibit the proliferation of calf vascular smooth muscle cells induced by platelet-derived growth factor. At 10 -4 mol/L, the inhibition rate can reach 50.6%. This provides an experimental basis for the anti-atherosclerotic effect of Hoshouwu.

cardioprotection
The study found that Polygonum multiflorum extract has a preventive effect on myocardial ischemia-reperfusion injury in dogs. The link of its action may be that stilbene glycosides and resveratrol glycosides in Polygonum multiflorum can increase the activities of superoxide dismutase (SOD) and catalase. In addition, some components in Polygonum multiflorum, such as anthraquinones and phospholipids, have direct antioxidant effects and reduce oxygen free radicals in the body.

Hepatoprotective effect
The stilbene glycosides contained in Polygonum multiflorum have significant antagonistic effects on fatty liver and liver function damage in rats caused by peroxidized corn oil, the increase in the content of lipid peroxidation in the liver, and the increase in serum alanine aminotransferase and aspartate aminotransferase. Serum free fatty acids and hepatic lipid peroxidation can be significantly decreased. In in vitro experiments, it can also inhibit the lipid peroxidation of rat liver microsomes caused by adenosine diphosphate and reduced coenzyme, reduce liver cell damage and have a good liver protection effect. In addition, Polygonum multiflorum is rich in lecithin, which can supplement or promote the synthesis of various liver diseases due to the reduction of lecithin, and prevent fatty liver and cholesterol deposition. And Polygonum multiflorum increases the effect of liver glycogen and is also beneficial to the protection of the liver.

neuroprotective effect
The main active ingredient in Polygonum multiflorum: stilbene glycoside has obvious antagonistic effect on the decrease of neuronal cell survival rate and the increase of lactate dehydrogenase leakage caused by β-amyloid and hydrogen peroxide. And with increasing dose, its neuroprotective effect is enhanced. It is s ested that stilbene glycosides have a certain effect on the prevention and treatment of senile dementia and other neurodegenerative diseases. The extract of Shouwu Fructus can inhibit the production of interleukin and nitric oxide in a concentration-dependent manner, thereby exerting a protective effect on neurons.

Antibacterial effect
Different processed products of Polygonum multiflorum decoction against Staphylococcus aureus, Staphylococcus albus, Shigella flexneri, Shigella sonnei, Typhoid Bacillus 901, Paratyphoid B, Diphtheria Bacillus, Beta Hemolytic Streptococcus, Nesthikata The bacteria have different degrees of inhibitory effect, among which the anti-S. The inhibitory ability of steamed Shouwu decoction on Diphtheria bacillus was better than that of raw products and other processed products.

Other role
Polygonum multiflorum has adrenocortical hormone-like effect, and making Shouwu Wu can significantly increase the content of liver glycogen in de-adrenal-starved mice, make the adrenal glands of mice significantly increase weight, and can fight against the thymus, Adrenal atrophy. In addition, the anthraquinone derivatives contained in Polygonum multiflorum can promote intestinal peristalsis and have a mild laxative effect.

Instructions
Polygonum multiflorum has a long history of being used in traditional Chinese medicine to treat liver and kidney disorders, as it is believed in ancient Chinese medicine to have the ability to nourish yin, which maintains the balance of a healthy body. In addition, ancient Chinese medicine believed that "the luster of hair is related to kidney function", and Polygonum multiflorum is widely used as a cosmetic orally or externally because of its ability to make hair black and shiny.
Dosage: 4:1 extract, 500-800mg, taken in two divided doses on an empty stomach.
Safety: Diarrhea patients and pregnant women should not take this medicine. Slight nausea, vomiting, bloating and bowel movement disorders may occur if overdose.

Company Introduction
Address: Room 202, Building B8, Huanchuang Enterprise Square, Lugu Street, Yuelu District, Changsha City, Hunan Province
Website: http://www.staherb.cn/
Business scope: Biotechnology, research and development of plant extracts (can be used in the field of pharmaceutical and health products, cosmetics, feed additives and biological pesticide production and development)
Main products: Eucommia extract - chlorogenic acid (5%-98%), ursolic acid (25%-98%), corosolic acid (1%-98%), bitter amygdalin (50%-98%), epimedoside (10%-98%) and other standardized high-purity plant extracts.

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