Caffeic acid CAS 331-39-5
| Model: | 331-39-5 |
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| Brand: | ZSpharmac |
| Origin: | Made In China |
| Category: | Chemicals / Chemical Waste / Cosmetics Chemicals |
| Label: | - |
| Price: |
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| Min. Order: | 1 pc |
Product Description
| Product Name: | Caffeic acid |
| Synonyms: | RARECHEM BK HC T335;TIMTEC-BB SBB006475;4-(2’-carboxyvinyl)-1,2-dihydroxybenzene;4-(2-Carboxyethenyl)-1,2-dihydroxybenzene;4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene;CAFFEIC ACID;3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID;3-(3,4-DIHYDROXYPHENYL)ACRYLIC ACID |
| CAS: | 331-39-5 |
| MF: | C9H8O4 |
| MW: | 180.16 |
| EINECS: | 206-361-2 |
| Product Categories: | Cosmetic Raw Materials; Organic Intermediates; Daily Chemical Raw Materials |
| Melting point | 211-213 °C (dec.) (lit.) |
| Boiling point | 272.96°C (rough estimate) |
| density | 1.2933 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL |
| pka | 4.58±0.10(Predicted) |
| form | powder |
| color | yellow to tan |
| Water Solubility | soluble in hot water |
| Physical and Chemical Properties | Caffeic acid, scientific name: "3-(3,4-dihydroxyphenyl)-2-propenoic acid." Molecular formula: C9H8O4; the molecular weight: 180.16. It is presented in plants such as coffee in the form of chlorogenic acid. It is yellow crystals with melting point being 223~225 °C. When it is precipitated in concentrated solution, it contains no crystal water. However, precipitate of crystals from dilute solution contains one molecule of crystallized water. It is slightly soluble in water, and easily soluble in hot water, cold ethanol, and ethyl acetate. Its alkaline solution is orange and exhibits dark green when being mixed with ferric chloride.
Application: caffeic acid is safe to be applied in cosmetics and has a broader antibacterial and antiviral activity. It can also absorb ultraviolet radiation. A low concentration of it already has inhibitory efficacy on the generation of skin melanin. Its applied amount in the beauty products for whitening is at the range of 0.5 to 2%. It can also be used as additive for the oxidized hair dyes which is good for enhancing the strength of the color. Preparation: it can be produced from the Perkin’s reaction between protocatechuic aldehyde and acetic acid,As follows:  |
| Extraction Method | Caffeic acid belongs to common phenolic compounds with effects of increasing the levels of white blood cells. It is easily to be confused with caffeine and is widely distributed in the plant kingdom. Its major plant sources include lemon peel, Ranunculaceae cimicifuga rhizome, and valerian root. Caffeic acid, together with ferulic acid, erucic acid, and p-hydroxy cinnamic acid are ubiquitous hydroxy cinnamic acid-class molecule distributed in various kinds of plants. This kind of products has conjugated double bonds in the side chain of the molecular structure, and thus exhibiting significant fluorescence upon ultraviolet light, mostly showing bluish color fluorescence. This is a advantage for paper chromatography tests or thin layer chromatography tests.
Extraction Method: Single spike cimicifuga rhizome is extracted with methanol which is removed through concentration under reduced pressure. Add hot water to the residue to dissolve it. Heating the water to dissolve the residue, and further filter the insolubles upon heating. After cooling, add benzene for extraction with the benzene solution being washed with 1% aqueous sodium bicarbonate and further collecting the washed solution. Add dilute hydrochloric acid for acidification, and then apply benzene to remove the free organic acid; Concentrate under reduced pressure to get rid of the benzene with the residue being the enriched product of caffeic acid. The above information is edited by the chemicalbook of Dai Xiongfeng. |
| Drugs for white blood cells increase | Caffeic acid is a kind of drugs for stopping bleeding as well as increasing the number of white blood cell with effects of contracting microvascular coagulation, improving the function of coagulation factors, and increasing white blood cells and platelets. It is suitable for preventing bleeding or stopping bleeding in surgeries as well as for stopping bleeding for bleeding diseases in internal medicine, and obstetrics and gynecology. It is also suitable for treating leukopenia and thrombocytopenia caused by a variety of reasons. |
| HPLC determination of caffeic acid in dandelion | [For the test] Compositae dandelion: Taraxacum mongolicum Hand. Mazz, Alkali land dandelion T. sinicum Kitag.
(1) Chromatographic conditions: take octadecylsilane silica gel as a filling agent; methanol-phosphate buffer (sodium dihydrogen phosphate 1.56g, add water to dissolve it in 1000 ml, add 1% of phosphoric acid solution for adjusting to pH 3.8 to 4.0, that’s it) (23:77) as the mobile phase; detection wavelength is 323 nm; column temperature should be 40 °C. Number of theoretical plates should be calculated according to the caffeic acid peak and should not be less than 3,000. (2) the preparation of the reference solution: take 7.5 mg of caffeic acid reference substance, accurately weigh it and transfer it into the 50ml volumetric flask; add methanol to certain scale, shake; take precise amount of 2ml and put into 10ml volumetric flask, add methanol to the scale , shake, to obtain the reference solution (containing caffeic acid 30μg per ml). (3) Preparation of sample solution: Take about 1 g of medicine powder, accurately weigh it, and put it in 50ml Erlenmeyer flask, precisely add 10 mL of methanol solution containing 5% formic acid, seal, shake, weigh, and subject to ultrasonic treatment for 30min, remove, cool, then weigh again; use the methanol solution of 5% formic acid to complement the weight loss, shake, centrifuge, and take the supernatant for being filtrated through microporous membrane (0.45μm) with the filtrate being placed in brown bottle to obtain the sample solution. (4) Determination: separately and precisely pipette 10μl of both reference solution and sample solution and transfer into the liquid chromatography for measurement. (5) Measurement results: calculated from the dry products of dandelion herbs, the caffeic acid content should not be less than 0.02%. |
| Chemical Properties | It is yellow crystals and can be dissolved in water and ethanol. |
| Uses | 1. Reagents for Organic Synthesis. 2. Intermediate of caffeic acid; can be used in organic synthesis. 3. Used for Biochemical studies. |
| Category | Toxic Chemicals |
| Toxicity grading | Poisoning |
| Acute toxicity | Intraperitoneal administration-rat LDL0: 1500 mg/kg |
| Flammability and hazard characteristics | Thermal decomposition causes irritating smoke |
| Storage Characteristics | Treasury: ventilation low-temperature and dry. |
| Extinguishing agent | Water, powder, CO2, foam. |
| Description | Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong), and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solution
Caffeic acid has both cis and trans isomers, and the two isomers of caffeic acid have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free state accounts for a few proportion. |
| Description | Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 μM and 12-LO with an IC50 value of 5.1-30 μM. |
| Chemical Properties | Light yellow to greenish-yellow powder |
| Physical properties | Appearance: yellow crystal. The crystal from the concentrated solution does not contain crystal water, and the crystal from the dilute solution contains one molecule crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in cold
water but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is orange-red. Ferric chloride solution was dark green. |
| Uses | Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis. It has also been used to determine its antioxidant activity by various assay methods. |
| Uses | antineoplastic, PGE2 synthase inhibitor, PK inhibitor |
| Uses | Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi. |
| Indications | It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia. |
Member Information
| Shandong Zhishang Chemical Co., Ltd. | |
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| Country/Region: | Shan Dong - China |
| Business Nature: | Trading Company |
| Phone: | 18888290058 |
| Contact: | William (General manager) |
| Last Online: | 20 Oct, 2021 |
