Model: | CAS 865854-05-3 |
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Brand: | 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidin |
Origin: | Made In China |
Category: | Chemicals / Organic Chemical Materials / Pharmaceutical Chemicals |
Label: | CAS 865854-05-3 , Small molecule inhib , Synthetic intermedia |
Price: |
US $25
/ kg
|
Min. Order: | 1 kg |
Product Description
Chemical Name:4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
CAS No.:865854-05-3
EINECS NO:640-411-8
MF: C19H14N2O2S
MW: 334.39
Density: 1.393
Melting point:148 - 150oC
Boiling point:511.3±43.0 °C(Predicted)
product modality:powder
color:white to beige
In vitro study
Tideglusib irreversibly inhibits GSK-3 in human neuroblastoma cells and primary neurons in mice, thereby reducing tau phosphorylation levels and preventing apoptosis. Tideglusib(2.5μM) inhibits glutamate-induced glial activation, as evidenced by decreased expression levels of TNF-α and COX-2 in primary astrocytes or microglia in rats. Tideglusib(2.5μM) also has an effective protective effect on cortical neurons against glutamate-induced neuroexcitatory toxicity. The evidence for this conclusion is that the number of Annexin-V positive cells in primary astrocytes or microglia in large Chemicalbook rats is significantly reduced
In vivo study
Tideglusib(50mg/kg) injected into the hippocampus of adult male Wistar rats can significantly reduce the rhodosine-induced inflammatory response and damage to the hippocampus The area has a protective effect. In APP/tau double-transgenic mice, Tideglusib(200mg/kg orally) reduced tau phosphorylation levels, reduced amyloid deposition and patk-associated astrocyte proliferation, protected neurons in the entorhinal cortex and hippocampal CA1 region from death, and prevented memory loss
Payment Terms: | T/T,L/C ,BITCOIN,Western Union,MoneyGram,DP |
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Anhui Jiakenuo Technoligy Co.,Ltd | |
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Country/Region: | An Hui - China |
Business Nature: | Manufacturer |
Phone: | 19966535427 |
Contact: | miya zhou (sales manager) |
Last Online: | 15 Nov, 2023 |