Product Name: Lesinurad

CAS No.: 878672-00-5

Information; URAT1 inhibitor

Other Names: RDEA 594;RDEA-594;RDEA594

Chemical Name: 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid

Canonical SMILES: C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O

MF: C17H14BrN3O2S

MW: 404.28

Purity: 99%

Type: Anti-gout Agents

Grade Standard: Medicine Grade

Model Number: API-Lesinurad

Solubility: Soluble in DMSO 

Storage: Store at -20°C 

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. 

Shipping Condition Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

Background: Lesinurad is an inhibitor of URAT1 that promoting renal uric acid excretion [1].URAT1 is a transporter in the kidney that regulates uric acid excretion from the body [2].

In the clinical study, lesinurad potently inhibit URAT1 as well as OAT4, another transporter responsible for the renal resorption of urate. In a study, 21 people with hyperuricemia or gout (sUA >= 8.0 mg/dL) were randomized to lesinurad, open-label allopurinol or placebo. Most of the lesinurad-treated patients had sUA < 6 mg/dL after seven days, which were the same effect to patients receiving allopurinol and better than placebo. Also, Lesinurad showed well tolerated in the study [2]. Compared with probenecid, whose efficacy is reducing patients with renal insufficiency, lesinurad may be effective in patients with mildly impaired renal function [1].

Brand Name: Huavet

Place of Origin: Shaanxi, China (Mainland)

USAGE: Pharmaceutical Intermediates

COA: Available

MSDS: Available

Spectrum: Available

Inventory status: in stock

Assay: 99% min

Shelf life: 2 years

Packaging Details: 1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial quantity. Specific packing required by customer

for Lesinurad.

Delivery Detail: Prompt shipment