Good quality and low price Factory supply Procaine Etomidate 99.8% white powder

Model:	33125-97-2
Brand:	MF
Origin:	Made In China
Category:	Chemicals / Pharmaceutical Chemicals
Label:	-
Price:	US $10 / gram
Min. Order:	5 gram

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Product Description

Description

Etomidate

Etomidate structure	Common Name	Etomidate
	CAS Number	33125-97-2	Molecular Weight	244.289
	Density	1.1±0.1 g/cm3	Boiling Point	391.5±17.0 °C at 760 mmHg
	Molecular Formula	C14H16N2O2	Melting Point	72-74ºC
	MSDS	Chinese USA	Flash Point	190.6±20.9 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Etomidate

Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response s ests that a major increase in adrenal hormone production may not be necessary during surgery [1]. Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure [2]. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality [3].Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.

Etomidate Biological Activity

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Research Areas >> Neurological Disease

Solvent

In Vitro:

10 mM in DMSO

Solubility

1 mM	4.0935 mL	20.4675 mL	40.9350 mL
5 mM	0.8187 mL	4.0935 mL	8.1870 mL
10 mM	0.4093 mL	2.0467 mL	4.0935 mL

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OCC

References

[1]. Griesdale, D.E., Etomidate for intubation of patients who have sepsis or septic shock - where do we go from here? Crit Care, 2012. 16(6): p. 189.

[2]. Cherfan, A.J., et al., Etomidate and mortality in cirrhotic patients with septic shock. BMC Clin Pharmacol, 2011. 11: p. 22.

[3]. Mehta, M.P., et al., Etomidate anesthesia inhibits the cortisol response to surgical stress. Acta Anaesthesiol Scand, 1985. 29(5): p. 486-9.

Related Molecules

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	391.5±17.0 °C at 760 mmHg
Melting Point	72-74ºC
Molecular Formula	C14H16N2O2
Molecular Weight	244.289
Flash Point	190.6±20.9 °C
Exact Mass	244.121185
PSA	44.12000
LogP	3.26
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.562
Storage condition	2-8°C
Water Solubility	DMSO: >10 mg/mL

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.