Product Description

Chemical Name: Phenacetin

CAS No.: 62-44-2
EINECS NO:200-533-0

MF:C10H13NO2

MW: 179.22
Density:1.1248 (rough estimate)
Melting point: 133-136 °C (lit.)

Boiling point: 132 °C / 4mmHg

Product modality: powder
Color: White

Product properties & Features

The antipyretic and analgesic effect of phenacetin is similar to that of acetylsalicylic acid. It is mainly used as antipyretic and analgesic drug with slow and lasting effect. It has good efficacy in the treatment of headache, neuralgia, arthralgia and fever, but has weak anti-rheumatism and anti-inflammatory effect. Excessive dose can lead to methemoglobin disease, resulting in hypoxia, long-term medication can damage the kidney, and even cause nipple necrosis, should be used with caution. Due to its toxic side effects and the rapid development of other similar drugs, the drug has been discontinued as a stand-alone drug, only as a bulk drug and other drugs in combination. Often combined with aspirin and caffeine to form compound aspirin, which consists of phenacetin 0.162g, aspirin 0.227g, caffeine 0Chemicalbook. 035g, less toxic, used to treat colds and colds. If a small amount of puermin is added to the above drugs, it can also be made into puermin cold tablets, which can be used to treat cold, headache, neuralgia, rheumatic pain, etc. Phenacetin itself has no antipyretic and analgesic effect, in the body, after metabolic decomposition of acetaminophen, paracetamol, to play a antipyretic and analgesic effect. Also decomposed p-aminophenether, p-aminophenether not only has no antipyretic analgesic effect, and the main factor of the toxic side effects of phenacetin. China began to produce phenacetin in 1954. Phenacetin is produced by etherification of nitrochlorobenzene with ethanol to obtain p-nitrophenyl ether, which is then reduced to p-aminophenyl ether and acetylated with acetic acid.

Application

The antipyretic effect of phenacetin is stronger than the analgesic effect. The effect intensity is similar to that of aspirin, the effect is slow and lasting, and the toxicity is low. The results show that the product and its metabolite paracetamol have antipyretic effect. Chemicalbook showed obvious antipyretic effect when phenacetin could not be converted to paracetamol with enzyme inhibitors. Therefore, the antipyretic effect of the drug is not only caused by its active product paracetamol.

Packing & Storage

We are the key player in the Phenacetin market. Our Phenacetin production capacity is 500 MT annually and keep expanding.

Packing: 20kgs/iron drum; 40kgs/iron drum; 600kgs/bag,or as customer’s requests;

Storage and transportation: Sealed in dry,Room Temperature