Melting point: 114-116°C
Predicted Boiling point: 451.7±45.0°C
Density: 1.1844(estimate)
Storage conditions: undChemicalbookerinertgas (nitrogenorArgon) at2-8 ° C
Acidity coefficient: (pKa)pKa9.51(Uncertain)
Paroxetine, (-) -trans-4 -(4-fluorophenyl)-3-[[3,4-(methodioxy) phenoxy] methyl] -piperidine, which is a selective 5-HT reuptake inhibitor, has no significant effect on other transmitters when used in common doses. Increase the concentration of Chemicalbook5-HT in the synaptic space by preventing the reabsorption of 5-HT, thus producing an antidepressant effect. Paroxetine works by inhibiting the reuptake of neurogenic 5-TH in the brain, and is more selective than fluoxetine, sertraline, or clomipramine. It has low affinity to cholinergic, histamine or adrenoergic receptors, and is less resistant to bile alkaline and cardiovascular adverse reactions than tricyclic antidepressants. It strongly and selectively inhibits the reabsorption of serotonin by synaptosomes without directly interfering with any central neurotransmitter receptors. Used for depression, especially anxiety and obsessive-compulsive disorder.