| Product Name: |
Recombinant Homo sapiens (Human) Protein CYR61
|
| Product Type : |
Recombinant Protein |
| Code : |
CSB-EP006463HU |
| Size : |
1mg/500ug/200ug/50ug/10ug |
| Uniprot NO. : |
O00622 |
| Storage : |
Store at -20℃, for extended storage, conserve at -20℃ or -80℃. |
| Relevance : |
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
| Image : |
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| References : |
"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts." Chen C.-C., Mo F.-E., Lau L.F. J. Biol. Chem. 276:47329-47337(2001) |
| Storage Buffer : |
20mM Tris-HCl based buffer,pH8.0 |
| Alias : |
CCN family member 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 Short name: IBP-10 Short name: IGF-binding protein 10 Short name: IGFBP-10 Protein GIG1 |
| Species : |
Homo sapiens (Human) |
| Purity : |
Greater than 90% as determined by SDS-PAGE. |
| Sequence : |
TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD |
| Research Area : |
Stem Cells |
| Protocol : |
Instructions
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
|
| Source : |
E.coli |
| Gene Names : |
CYR61 |
| Expression Region : |
25-381aa |
| Notes : |
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week. |
| Product Info : |
His-SUMO-tag |
| Mol. Weight : |
55.41kD |
| Protein Description : |
Full length |
